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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Molecular and functional signatures in a novel Alzheimer’s disease mouse model assessed by quantitative proteomics

Fig. 5

Protein clustering reveals major biological and molecular signatures of ADLPAPT mice. a Hierarchical clustering of differentially expressed proteins (DEPAPTs) between ADLPAPT and wild-type mice (732 proteins; ANOVA FDR < 0.05). The DEPsAPT were clustered into five types of expression pattern. The protein expression level is the normalized protein abundance represented after Z-normalization. Scatter plot of enriched Gene Ontology (GO) terms in protein cluster 2 (down-regulated proteins) and cluster 5 (up-regulated proteins) are shown in the right panel. The -log10 (P-value) is plotted against the fold-enrichment of each GO term. b Heatmaps showing the expression levels of the proteins involved in the GO terms, such as synapse proteins and cytoskeleton binding proteins, in cluster 2 (down-regulated proteins). c Heatmaps for the expression levels of co-regulated proteins corresponding to the GO terms, such as lysosome, endosome, leukocyte-mediated immunity, and phagocytosis, in cluster 5 (up-regulated proteins)

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