Fig. 6

Prediction of molecular responses to AD pathology in ADLP^APT mice. a Hierarchical clustering of downstream biological functions (lower panel) and the upstream regulators (upper panel) assessed by IPA using 732 DEPs^APT (ANOVA FDR < 0.05). The predictive activation/inhibition status is shown as a Z-score. b Graphical representation of the protein expression levels of members of the leukocyte extravasation pathway and (c) the synaptic long-term potentiation pathway in 10-month-old ADLP^APT mice. Individual proteins’ fold-change values to the wild type were visualized in color (blue: down-regulation, red: up-regulation). Glu = Glutamate, PIP2 = Phosphatidylinositol 4,5-bisphosphate, DAG = Diacylglycerol, IP3 = Inositol 1,4,5-trisphosphate, ATP = Adenosine triphosphate, cAMP = Cyclic adenosine monophosphate