Fig. 4

Piperine treatment improved motor performances of TBP-105Q KI mice. Three-month old WT and TBP-105Q KI mice were treated with either piperine (10 mg/kg, WT + Pip and TBP + Pip) or saline (WT + NS and TBP + NS) via daily oral gavage for 2 months (n = 10 for each group). Different behavioral tests were performed every 2 weeks. a-d TBP-105Q KI mice treated with piperine showed significant improvement in grip strength (a) and balance beam (b) tests compared with TBP-105Q KI mice treated with saline. TBP-105Q KI mice treated with piperine showed comparable rotarod performances as TBP-105Q KI mice treated with saline (c). The body weight of TBP-105Q KI mice treated with piperine was increased compared with TBP-105Q KI mice treated with saline (d). ** P < 0.01, *** P < 0.001. Results are presented as means ± SEM. e A representative image of 5-month-old TBP-105Q KI mice after 2 months of treatment with either piperine or saline. The black arrow indicates the mice treated with piperine