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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration

Fig. 1

Expression of hTTBK1-cat causes neurodegenerative phenotypes in a tau background. a Staged hTTBK1-cat;tau transgenic L4 larvae exhibit significantly decreased radial velocity relative to tau(low) and (b) tau(high) transgenic animals. Animals were measured for the linear distance traveled from a central reference point over 1 h, N > 70 for each genotype. Significance was determined using an unpaired T-test. P < 0.0001 versus tau(low) and P < 0.0001 versus tau(high). c hTTBK1-cat;tau(low) transgenic animals have increased total tau and ptau relative to tau(low) animals. Bar graphs represent four independent replicate immunoblots of (d) Total tau, (e) pThr181, (f) pSer202, (g) pThr231, and (h) pSer396/404. Graphs are plotted in relative intensity. Significance was determined using an unpaired T-test. P < 0.05 (*), P < 0.01 (**), P < 0.001 (***). i hTTBK1-cat;tau(high) transgenic animals have increased total tau and ptau relative to tau(high) animals. Bar graphs represent four independent replicate immunoblots of (j) Total tau, (k) pThr181, (l) pSer202, (m) pThr231, and (n) pSer396/404. Graphs represent densitometry analysis and are plotted in relative intensity. Significance was determined using an unpaired T-test. P < 0.05 (*), P < 0.01 (**), P < 0.001 (***)

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