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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration

Fig. 2

Expression of hTTBK2-cat causes neurodegenerative phenotypes in a tau background. a Staged hTTBK2-cat;tau(low) transgenic L4 larvae exhibit significantly decreased radial velocity relative to tau(low) and (b) tau(high) transgenic animals. Animals were measured for the linear distance traveled from a central reference point over 1 h, n > 75 for each genotype. Significance was determined using an unpaired T-test. P < 0.0001. (b) hTTBK2-cat;tau transgenic animals have increased total tau and ptau relative to tau animals. Bar graphs represent four independent replicate immunoblots of (c) Total tau, (d) pThr181, (e) pSer202, (f) pThr231, and (g) pSer396/404. Graphs represent densitometry analysis and are plotted in relative intensity. Significance was determined using an unpaired T-test. P < 0.05 (*), P < 0.01 (**), P < 0.001 (***)

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