Fig. 5
From: Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration
Expression of hTTBK1-cat causes neurodegenerative phenotypes in a TDP-43 background. a Staged hTTBK1-cat; TDP-43 transgenic L4 larvae exhibit significantly decreased radial velocity relative to TDP-43 transgenic animals. Animals were measured for the linear distance traveled from a central reference point over 1 h, N > 90 for each genotype. Significance was determined using an unpaired T-test. P < 0.01 versus TDP-43. b hTTBK1-cat; TDP-43 transgenic animals have increased total TDP-43 and pTDP-43 relative to TDP-43 animals. Bar graphs represent six independent replicate immunoblots of (c) Total TDP and (d) pTDP. Graphs are plotted in relative intensity. Significance was determined using an unpaired T-test. P < 0.05 (*), P < 0.01 (**), P < 0.001 (***)