Table 1 Expression of TTBK2-cat is embryonic lethal in a high-expression tau homozygous background
From: Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration
(Homozygous for TTBK2) | Observed | Expected |
tau +/+ | 6 (3.6%) | 41 (25%) |
tau +/− | 30 (18.2%) | 83 (50%) |
tau −/− | 50 (30.3%) | 41 (25%) |
Larval Dead | 47 (28.5%) | 0 (0%) |
Adult Sterile | 32 (19.4%) | 0 (0%) |
Total | 165 | |
(Homozygous for tau) | Observed | Expected |
TTBK2 +/+ | 18 (7.1%) | 63.5 (25%) |
TTBK2 +/− | 99 (39.0%) | 127 (50%) |
TTBK2 −/− | 61 (26.5%) | 63.5 (25%) |
Larval Dead | 46 (18.1%) | 0 (0%) |
Adult Sterile | 30 (11.8%) | 0 (0%) |
Total | 254 |