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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex

Fig. 3

Mfn2 ablation caused abnormal mitochondrial distribution in vivo. a Rerpresentative electron micrographs of a segment of axon of CA1 neuron from hippocampus of control and Mfn2 cKO mice. Immunohistochemistry using OXPHOS cocktail antibody to stain mitochondria finds many neurons in the hippocampus (b) and frontal cortex (c) exhibiting staining throughout the cell body and processes in the control mice. However, at as early as 8 weeks, a striking loss of neuronal process immunolocalization in the CA1 and cortical neurons occurs and becomes more apparent with aging

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