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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex

Fig. 6

Mfn2 ablation caused increased oxidative stress in the hippocampus and cortex in vivo. a Representative of DNP adduction immunochemical assay to detect protein oxidation in the hippocampus of Mfn2 cKO mice and control mice. Representative western blots (b) and quantification analysis (c) showed significant increase in protein oxidation in 8-week-old Mfn2 cKO mice compared to age-matched control mice using the DNP assay. Actin was used as an internal loading control. (Data represent mean ± SEM, Student’s t-test, *P < 0.05). d-e Representative immunohistochemistry of anti-HO-1, an inducible antioxidant enzyme, in the hippocampus (d) and cortex (e) of Mfn2 cKO mice and control mice

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Molecular Neurodegeneration

ISSN: 1750-1326