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Fig. 10 | Molecular Neurodegeneration

Fig. 10

From: BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

Fig. 10

BACE1-mediated cleavage of CHL1 is reduced in human brains from subjects affected by Down syndrome. a Representative immunoblot of TBS soluble fraction (Soluble) and membrane fraction (Membrane) of the human hippocampus samples from subjects with Down Syndrome (DS) or unaffected Controls (Ctrl) using anti-human CHL1 (MAB2126), anti-calnexin (610523), and anti-GAPDH (MAB374) antibodies. b Graphs represent the ratio CHL1_FL/Calnexin, CHL1_βNTF/GAPDH, and CHL1βNTF/CHL1_FL in five different genotypes. All graphs represent mean ± SEM. Unpaired t-test with Welch’s correction was performed. * p < 0.05, ** p < 0.01 c Linear correlation analysis between CHL1_FL and APP levels in Down Syndrome and Control cases. CHL1_FL levels are significantly correlated with membrane-bound APP levels in both DS and Ctrl cases. The dotted line represents 95% confidence interval

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