TY - JOUR AU - Jeong, Ga Ram AU - Jang, Eun-Hae AU - Bae, Jae Ryul AU - Jun, Soyoung AU - Kang, Ho Chul AU - Park, Chi-Hu AU - Shin, Joo-Ho AU - Yamamoto, Yukio AU - Tanaka-Yamamoto, Keiko AU - Dawson, Valina L. AU - Dawson, Ted M. AU - Hur, Eun-Mi AU - Lee, Byoung Dae PY - 2018 DA - 2018/02/13 TI - Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration JO - Molecular Neurodegeneration SP - 8 VL - 13 IS - 1 AB - Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson’s disease (PD). Elevated kinase activity is associated with LRRK2 toxicity, but the substrates that mediate neurodegeneration remain poorly defined. Given the increasing evidence suggesting a role of LRRK2 in membrane and vesicle trafficking, here we systemically screened Rab GTPases, core regulators of vesicular dynamics, as potential substrates of LRRK2 and investigated the functional consequence of such phosphorylation in cells and in vivo. SN - 1750-1326 UR - https://doi.org/10.1186/s13024-018-0240-1 DO - 10.1186/s13024-018-0240-1 ID - Jeong2018 ER -