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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

Fig. 7

Phosphomutants of Rab35 induce degeneration of dopaminergic neurons in the substantia nigra. a Tyrosine hydroxylase (TH) immunostaining in the substantia nigra at 3 weeks after adeno-associated virus (AAV)-mediated delivery of wild-type (WT) or phosphomutants (T72A or T72D) of Rab35. AAV-eGFP was injected as a control. b, c Quantification of TH- (b) and Nissl-positive (c) neurons in the substantia nigra in the contralateral and ipsilateral side. Data are mean ± SD (n = 5). * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001, n.s. statistically not significant; one-way ANOVA followed by Tukey’s post hoc analysis. Scale bar, 1 mm

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