Fig. 1
From: Extracellular α-synuclein levels are regulated by neuronal activity
Modulating neuronal activity alters α-synuclein release from neurons. a TTX (1 μM, 30 min) decreased α-synuclein in the media. N = 12–16. b Glutamate (10 μM, 30 min) increased α-synuclein in the media, which was blocked by 50 μM AP5 and 10 μM NBQX. N = 8–20. c Cellular α-synuclein levels were not altered by glutamate. N = 8. d LDH activities in the media after indicated pharmacological treatments. N = 8–28. mean ± SEM, **p < 0.01, ***p < 0.001, ****p < 0.0001 using unpaired t test (a, c) or one-way ANOVA (b, d)