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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Genetic ablation of dynactin p150Glued in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice

Fig. 2

Dynein/dynactin complex remains intact in Dctn1LoxP/LoxP; Cre/Esr1 neurons. a-b Sucrose density gradient centrifugation shows p150Glued and p135+ predominantly migrate at fraction 4 and 5 in a 5–20% sucrose gradient similar to the other dynactin subunits p62, p50, and ARP1, as well as the dynactin-interacting dynein subunit DIC in the control Dctn1LoxP/LoxP (a) and p150Glued cKO Dctn1LoxP/LoxP; Cre/Esr1 cortical neuron cultures (b) at 7 DIV

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