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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Genetic ablation of dynactin p150Glued in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice

Fig. 3

Selective deletion of neuronal p150Glued in brain and spinal cord of Dctn1LoxP/LoxP; Thy1-Cre mice. a Representative images show p150Glued (green) and NeuN (blue) staining in the sagittal brain sections of 3-month-old Dctn1LoxP/LoxP and Dctn1LoxP/LoxP; Thy1-Cre mice. Arrows point to olfactory bulb (OB), cortex (CX) and hippocampus (HP) with intense p150Glued staining in Dctn1LoxP/LoxP mice and weak p150Glued staining in Dctn1LoxP/LoxP; Thy1-Cre mice. Scale bar: 500 μm. b Representative images show p150Glued (green) and p150Glued/p135+ (purple) expression in the CTIP2-positive (red) CSMNs of 3-month-old Dctn1LoxP/LoxP and Dctn1LoxP/LoxP; Thy1-Cre mice. Scale bar: 500 μm. c Representative images show p150Glued (green) and CHAT (blue) staining in the lumbar spinal cord sections of 3-month-old Dctn1LoxP/LoxP and Dctn1LoxP/LoxP; Thy1-Cre mice. Arrows point to the CHAT-positive SMNs. Scale bar: 500 μm. d Representative images show p150Glued (green) and p150Glued/p135+ (red) expression in the NeuN-positive SMNs of 3-month-old Dctn1LoxP/LoxP and Dctn1LoxP/LoxP; Thy1-Cre mice. Scale bar: 20 μm

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