Fig. 4

Dctn1^LoxP/LoxP; Thy1-Cre mice develop abnormal motor phenotypes. a-d Male Dctn1^LoxP/LoxP, Dctn1^+/+; Thy1-Cre and Dctn1^LoxP/LoxP; Thy1-Cre mice (n ≥ 10 per genotype per time point) were measured for body weight (a); tested for the ambulatory movement (b) and rearing movement (c) in Open-field; and examined for the latency to fall in Rotarod test (d) at 1, 3, 6, 12 and 18 months of age. Data were presented as mean ± SEM. One-way ANOVA plus Tukey’s post hoc test was used for statistical analysis. c At 18 months of age, ^*p < 0.05 for difference against Dctn1^LoxP/LoxP; Thy1-Cre, while no difference was found between Dctn1^LoxP/LoxP and Dctn1^+/+; Thy1-Cre. d At 12 or 18 months of age, ^*p < 0.05 or ^***p < 0.001 for difference against Dctn1^LoxP/LoxP; Thy1-Cre, respectively, while no difference was found between Dctn1^LoxP/LoxP and Dctn1^+/+; Thy1-Cre