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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease

Fig. 1

Intraneuronal amyloid and neuritic plaques are present in 5 mo 5XFAD mice. Representative 63× images of intraneuronal amyloid (asterisk), neuritic plaques (arrows) with DAPI-positive core (blue) surrounded by a 6E10-positive amyloid rim (green) and Iba1-positive cells (red) in cortex, hippocampus and amygdala. Arrowheads point to non-neuritic 6E10-positive plaques without a DAPI-positive center. The confocal acquisition was applied and a total z-plane of 10 μm was merged into single overlay images. Bar = 30 μm

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Molecular Neurodegeneration

ISSN: 1750-1326