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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease

Fig. 2

Long-term administration of PLX3397 ablates microglia and reduces neuritic plaque formation in 5XFAD mice. Top panels: representative 20× images of coronal brain sections with immunolabeling of microglia (Iba1, red) and staining for amyloid Aβ (6E10, green) in five-month-old 5XFAD mice kept on a standard diet or fed for 3 months with PLX3397 (290 mg/kg). Bottom panels: representative images of magnified regions of (1) hippocampus, (2) cortex, (3) thalamus and (4) amygdalar nucleus. The confocal acquisition was applied and a total z-plane of 30 μm was scanned across all regions and merged into single overlay images

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Molecular Neurodegeneration

ISSN: 1750-1326