Fig. 1
From: Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy
Tau oligomers are associated with α-synuclein toxicity. a Tau oligomers in A53T mice detected with T22 are elevated compared to non-transgenic controls. b Tau oligomers with T22 (red) are found in the vicinity of α-synuclein oligomers (green) in A53T mouse brains. c Western blot with Tau5 shows elevated oligomeric tau in A53T mice compared to non-transgenic (WT) controls. Recombinant tau oligomers (TO). d Western blot with TOMA shows detection of tau oligomers in PBS soluble (sol) and Sarkosyl soluble (insol) A53T mouse brain. e ELISA analysis of the PBS soluble fraction from whole brain shows that tau oligomer levels in the A53T mouse model are elevated compared to wild-type mice and increase with age. f Elevated levels of tau oligomers are detected in the PBS soluble brain homogenate of PD patients by Western blot with TOMA and a pan-tau antibody. g Non-denaturing filter trap assay demonstrates specificity of tau oligomer-specific antibodies. **p < 0.01