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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

Fig. 2

TOMA protects A53T mice from behavioral deficits. a Timeline for experimental design. b TOMA-treated animals are protected against memory deficits in the NOR. Control IgG-treated A53T mice have significantly lower discrimination index scores on the NOR when compared to wildtype mice (p = 0.0099) while TOMA-treated mice do not perform significantly differently than wildtype. c TOMA treatment protects against gait abnormalities in the footprint task. Control-IgG-treated mice have significantly greater separation between front and hind footprints when compared to wildtype (p = 0.048), while TOMA-treated mice do not perform differently than wildtype. d Control IgG antibody have significantly lower scores for nesting quality when compared to Wild-type controls (p = 0.0001) and TOMA-treated mice (p = 0.028), while TOMA-treated mice display nesting quality scores similar to wildtype. TOMA (n = 17), Ctrl IgG (n = 23), Wildtype (n = 16)

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