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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

Fig. 5

TOMA-treated mice are protected against dopamine loss in the olfactory bulb, synaptic dysfunction and premature death. a Representative images of olfactory bulb labeled with Tyrosine Hydroxylase (TH). b Number of TH-positive cells were significantly decreased in Control IgG-treated mice when compared to Wildtype (p = 0.001). TOMA-treated mice did not have significantly different levels of TH to Wildtype, but were significantly increased compared to Control IgG mice (p = 0.028). c and e Levels of synapsin 1 detected in the PBS soluble fraction of total brain homogenate by Western blot are significantly increased in TOMA-treated mice when compared to Control IgG (p = 0.003). d-e Synaptophysin levels are elevated in TOMA-treated mice approaching significance compared to control (p = 0.07). f Kaplan–Meier Survival Curves comparing Wildtype, Control IgG A53T and TOMA A53T mice. Control IgG-treated mice demonstrate a statistically significant (p = 0.019) increase in premature death rate when compared to Wildtype mice, while TOMA mice are not significantly different from either group. Scale bar 20 μm

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