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Table 2 Body weight, adiposity-related parameters, serum parameters, and HOMA-IR index

From: Cognitive impairment in metabolically-obese, normal-weight rats: identification of early biomarkers in peripheral blood mononuclear cells

 

NF

HF45

HF60

Body weight (g)

477 (27)

 

466 (23)

 

472 (32)

 

Fat mass (%)

18.4 (3.3)

a

20.5 (4.8)

a,b

23.4 (4.5)

b*

Adiposity index (%)

9.32 (1.51)

a

11.2 (2.5)

a,b

13.5 (2.7)

b*

Weight of adipose tissues (g)

      

eWAT

14.0 (2.1)

a

16.0 (4.5)

a,b

18.1 (5.5)

b*

iWAT

11.9 (2.5)

a

16.1 (4.6)

a,b*

15.7 (5.0)

b*

mWAT

6.89 (1.87)

 

7.05 (2.92)

 

7.90 (2.18)

 

rWAT

11.9 (3.2)

a

13.6 (4.2)

a,b

17.6 (6.1)

b*

Visceral fat content (g)

32.1 (6.9)

a

36.6 (10.9)

a,b

43.6 (13.1)

b*

Liver fat content (mg/ g liver)

38.3 (6.2)

a

57.9 (15.4)

b*

56.2 (11.9)

b*

Glucose (mg·dl−1)

Feeding

93.3 (9.4)

a

106 (5.5)

b*

111 (13.3)

b*

Fasting

89.6 (7.4)

a

98.4 (8.4)

b*

97.4 (7.1)

b*

Insulin (μg·l−1)

Feeding

2.21 (0.85)

 

1.88 (0.89)

 

1.68 (0.67)

 

Fasting

0.32 (0.11)

a

0.51 (0.28)

a,b

0.80 (0.37)

b*

HOMA-IR

1.7 (0.7)

a

2.8 (1.6)

a,b

4.5 (2.1)

b*

  1. Data correspond to male Wistar rats fed a control diet (NF), a moderate high-fat diet (45% kcal from fats, HF45 group), or a very high-fat diet (60% kcal from fats, HF60 group) from the age of 2 months until the age of 6 months. Food in HF groups was offered in isocaloric amounts to the control group
  2. Abbreviations: eWAT epididymal white adipose tissue; iWAT inguinal WAT; mWAT mesenteric WAT; rWAT retroperitoneal WAT
  3. Results represent mean (SD) (n = 10 in all groups). Statistics: *different vs control group (Student’s t test, p < 0.05). A one-way ANOVA was performed followed by an LSD post hoc test. Values not sharing a common letter (a, b) are significantly different (p < 0.05). No letters = no statistical difference