Fig. 1

Characterization of BBB permeability following TBI. (a) Increased EB extravasation in the ipsilateral cortex of wildtype mice at 1 (***p < 0.001, *p < 0.05; n = 4) and 3 days post-injury compared to sham. No change is observed in the (b) contralateral cortex (n = 4), (c) ipsilateral Thalamus/Striatum (n = 4) or (d) contralateral Thalamus/Striatum (n = 4) compared to sham. (e) T1-weighted MRI images representing the range of pericontusional leakage across bregma brain coordinates of a single wildtype mouse, at 3 days post-TBI. (f) T1-weighted MRI images displaying wildtype mice pre-injection and at 1, 3, 7, 14 and 21 days post-TBI. (g) Quantification of the T1-weighted MRI time course of BBB leakage post TBI ((**p < 0.01, *p < 0.05 vs Day 14 and Day 21; n = 3 per group). The intensity of signal increases from blue<green. Data expressed as mean ± S.E.M. One way ANOVA with Dunnett post hoc test