Fig. 2
From: Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology
Localization of tau MC1 immunoreactivity versus G85R-SOD1:YFP pathology in bigenic JNPL3/G85R-SOD1:YFP mice. Misfolded human tau recognized by the MC1 antibody (red) appears similar in JNPL3 tau-transgenic versus JNPL3/G85R-SOD1:YFP bigenic animals (a, b). G85R-SOD1:YFP pathology, detected by an YFP antibody (green) (c), does not robustly co-localize with tau pathology in double transgenic animals (d). Nuclei were stained with DAPI (blue). Representative images (60× magnification) are shown within the ventral horn of the spinal cord of 8 JNPL3 and 8 JNPL3/G85R-SOD1:YFP animals. All animals analyzed were female aged 7 to 15.5 months