Skip to main content
Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

Fig. 2

Microglial co-expression modules recapitulate homeostatic and DAM profiles and predict heterogeneity within DAM. a 2D-representation of trait-associated WGCNA modules using viSNE. Space between two clusters of genes is an arbitrary representation of dissimilarity or anti-correlation between expression patterns. b Mapping of DAM and homeostatic signature genes to WGCNA modules shows clustering of DAM genes to Yellow and Magenta modules and of Homeostatic genes to the Blue module. Genes shown in Grey represent those that were either not classified as DAM or homeostatic or were not identified by single cell RNAseq [9]. c Key transcriptional regulators, membrane-associated drug targets and predicted functional phenotypes of Blue, Magenta and Yellow AD-associated microglial modules (also see Additional file 7)

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326