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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

Fig. 5

CMAP analysis pro-inflammatory and anti-inflammatory DAM genes reveals genetic and chemical perturbagens as selective modulators. a Venn diagram representing exclusive members and dual members of Magenta and Yellow microglial modules. b Distribution of perturbagens from connectivity map (CMAP) analysis based on a median summary score (range − 100 to + 100) that represents likelihood of the perturbagen resulting in the desired transcriptional profile. c, d For these analyses, the desired transcriptional profile was upregulation of anti-inflammatory and down-regulation of pro-inflammatory module expression. A summary score ≥ + 90 typically indicates a high likelihood of achieving the desired profile (c, ↓Magenta/pro-inflammatory ↑Yellow/anti-inflammatory) while a score ≤ − 90 indicates likelihood of the opposite transcriptional profile (d, ↑Magenta/pro-inflammatory ↓Yellow/anti-inflammatory). The most significant chemical perturbagens (existing drugs) and genetic perturbagens (gene suppression or over-expression) are shown

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