TY - JOUR AU - Hettinger, Jane C. AU - Lee, Hyo AU - Bu, Guojun AU - Holtzman, David M. AU - Cirrito, John R. PY - 2018 DA - 2018/05/15 TI - AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model JO - Molecular Neurodegeneration SP - 22 VL - 13 IS - 1 AB - Extracellular aggregation of the amyloid-β (Aβ) peptide into toxic multimers is a key event in Alzheimer’s disease (AD) pathogenesis. Aβ aggregation is concentration-dependent, with higher concentrations of Aβ much more likely to form toxic species. The processes that regulate extracellular levels of Aβ therefore stand to directly affect AD pathology onset. Studies from our lab and others have demonstrated that synaptic activity is a critical regulator of Aβ production through both presynaptic and postsynaptic mechanisms. AMPA receptors (AMPA-Rs), as the most abundant ionotropic glutamate receptors, have the potential to greatly impact Aβ levels. SN - 1750-1326 UR - https://doi.org/10.1186/s13024-018-0256-6 DO - 10.1186/s13024-018-0256-6 ID - Hettinger2018 ER -