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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model

Fig. 4

8 and 14 h AMPA treatment does not alter expression of genes related to Aβ metabolism. 5 μM AMPA or vehicle was given to 2–4 month old APP/PS1 mice for 8 h (a) or 14 h (b; n = 6 per group) before the hippocampal tissue surrounding the microdialysis probe was collected and analyzed with quantitative PCR. a qPCR analysis revealed no differences in expression for major genes involved in Aβ production and clearance between mice treated with AMPA or vehicle. Expression of cFos, a marker for neuronal activity, increased 7.5 ± 3.7 fold (p < 0.0001, two-way ANOVA, Sidak post hoc test) for the AMPA-treated group over cFos expression in controls. b After 14 h of AMPA treatment, expression of genes involved in Aβ processing was not changed as shown by qPCR analysis. AMPA-treated animals showed a 14.4 ± 1.8 fold increase in cFos expression over controls (p < 0.0001, two-way ANOVA, Sidak post hoc test). Data plotted as mean ± SEM

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