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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: 2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling

Fig. 1

Human induced pluripotent stem cells (hiPSCs) in neurodegenerative diseases modelling. Patient-derived somatic cells (SCs) can be genetically reprogrammed to generate iPSCs. High-tech systems can be used to culture and differentiate iPSCs into brain cells such as oligodendrocytes, astrocytes and different neuronal populations (NPs), providing the possibility to accurately study neurodegenerative diseases in vitro and to obtain essential information about disease phenotype and pathology insights. This strategy provides the possibility of testing drugs in vitro and identifying new therapies for incurable disorders such as Alzheimer’s (AD), Parkinson’s (PD), Huntington’s (HD) diseases and amyotrophic lateral sclerosis (ALS). (Illustrations obtained from https://smart.servier.com/)

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