Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse

Table 2 Pridopidine treatment signal significantly reverses YAC128 HD signal. Numbers shown are adjusted p-values from Gene Set Enrichment Analysis

Dose	Direction	Striatum	Hippocampus	Cortex
10 mg/kg	Up in YAC128, Down with pridopidine	3.58E-04	3.78E-04	2.40E-04
10 mg/kg	Down in YAC128, Up with pridopidine	3.64E-04	4.99E-02	2.40E-04
30 mg/kg	Up in YAC128, Down with pridopidine	3.15E-04	3.46E-04	2.35E-04
30 mg/kg	Down in YAC128, Up with pridopidine	3.37E-04	3.53E-03	2.35E-04

Reversal was significant for all doses of pridopidine across the striatum, hippocampus, and cortex of YAC128 mice

ISSN: 1750-1326