Skip to main content
Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Fig. 1

Experimental design and behavioural testing in SCA3 mice. a MJD84.2 hemizygous mice were used as a model for SCA3. At indicated time points, plasma was collected for metabolic and lipidomic analyses, and whole blood was collected for RNA sequencing purposes. At 17.5 months of age, mice were sacrificed and 4 brain regions were isolated for RNA sequencing. b SCA3 mice show significantly lower bodyweight compared to wild-type mice. c The beamwalk balance test shows identical performance in coordination/balance performance of SCA3 and wild-type mice, apart from a better performance of SCA3 mice at 12 months of age. Depicted data represents 8 wild-type vs 8 SCA3 mice. Shown is mean +/− SEM, * = p < 0.05 using multiple t-test

Back to article page