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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Fig. 2

RNA sequencing results for SCA3 mouse brain. a Venn diagram depicting overlap of significantly altered genes (FDR < 0.05) from RNA sequencing analysis between SCA3 and wild-type mice per brain region. Six genes were common to all four regions. b Plots of the 6 most significantly altered genes in SCA3 mouse brain (combined regions). Expression values of genes are depicted separately for the 4 tested brain regions. * = FDR < 0.01 c qPCR validation on equimolar cDNA from the 4 brain regions, as well as separately in brainstem confirms significant gene expression changes. Based on 7 wild-type vs 6 SCA3 mice at 17.5 months of age. * = FDR < 0.01. Actb, Hprt and Rpl22 were used as reference genes

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