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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Fig. 3

Protein validation of RNA sequencing results in SCA3 mouse brain. Western blot analysis of mouse brain lysates from cerebellum (a) and cortex (b) probed for Car2 and Psat1 protein. Depicted are results of 4 wild-type and 3 SCA3 mice. c Quantification of band intensity reveals significant downregulation of Car2 protein in cerebellum and cortex of SCA3 mice, and significant upregulation of Psat1 in cerebellum. Protein expression was corrected per lane for β-actin levels. Based on 8 wild-type vs 6 SCA3 mice. * = p-value < 0.05 with student’s t-test

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Molecular Neurodegeneration

ISSN: 1750-1326