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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Fig. 4

Affected pathways in SCA3 mouse brain. a Brainstem and striatum present with different top affected pathways based on gene expression analysis. Expression of synaptic transmission associated genes in striatum (b) and brainstem (c) of wild-type and SCA3 mice confirm that the transcriptional changes in this pathway are specific to striatum. Obtained from RNA sequencing of 8 wild-type and 6 SCA3 mice. Depicted are 10 out the 23 differentially expressed genes within synaptic transmission pathway

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Molecular Neurodegeneration

ISSN: 1750-1326