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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Fig. 5

top 5 differentially expressed genes in blood of SCA3 mice. At 17.5 months 142 genes were differentially expressed (FDR < 0.05). a Normalized expression of top 5 differentially expressed genes at 17.5 months of age in blood of wild-type and SCA3 mice as detected by RNA sequencing. b qPCR validation of blood RNA confirms significant gene expression changes for Scrib and Atp13a2. Based on 8 wild-type vs 6 SCA3 mice at 17.5 months of age. * = FDR < 0.05. Actb, Vcl and Hprt (right columns) were used as reference genes

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Molecular Neurodegeneration

ISSN: 1750-1326