Table 3 Top overrepresented pathways for genes differentially expressed in SCA3 mouse brain
Pathway | Number of genes | p-value | Pathway database |
|---|---|---|---|
Brain regions combined analysis (585 genes) | |||
 α-adrenergic signalling | 11 | 1.23E-05 | IPA |
 CREB signalling in neurons | 25 | 1.95E-05 | IPA |
 Protein kinase A signalling | 25 | 2.57E-05 | IPA |
 Axon guidance | 24 | 3.63E-05 | IPA + Euretos |
 Transmission across chemical synapses | 13 | 5.50E-05 | IPA + Euretos |
 Superpathway of cholesterol biosynthesis (srebp) | 6 | 6.03E-05 | IPA + Euretos |
 Myelination (cellular process) | 24 | 8.02E-06 | IPA + Euretos |
Brainstem (195 genes) | |||
 pi-3 k cascade | 6 | 1.20E-04 | IPA + Euretos |
 amino acid metabolism | 9 | 1.31E-04 | Euretos |
 Superpathway of Cholesterol Biosynthesis | 5 | 1.74E-04 | IPA + Euretos |
Striatum (824 genes) | |||
 axon guidance | 38 | 2.19E-07 | IPA + Euretos |
 neurotransmitter receptor binding and downstream transmission in the postsynaptic cell | 19 | 9.72E-06 | Euretos |
 synaptic transmission/long term potentiation | 23 | 3.02E-05 | IPA + Euretos |