Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Table 5 Top altered blood metabolites in SCA3 mice at 3 time points

Compound	ChEBI ID	Fold change	p-value	Altered at Time points	Associated pathway
4 months
DL-Dihydroorotic-acid	17025	1.61 ± 0.19	0.002	4 months	Pyrimidine Metabolism
N-a-acetyl-L-arginine	40521	1.95 ± 0.39	0.003	4 months	NA
3-hydroxydecanoic-acid / 10-hydroxydecanoic-acid	17409	1.51 ± 0.21	0.005	4 months	Fatty Acid
12 months
L-Threonic-acid	15908	0.55 ± 0.08	0.001	12 months	Ascorbate and aldarate metabolism
2-Aminoisobutyric-acid / Aminobutyric-acid	27971	2.58 ± 0.69	0.002	12 months	NA
Asparagine	17196	0.68 ± 0.08	0.003	12 months	Ammonia Recycling / Aspartate Metabolism / Transcription/Translation
16 months
Methylhistamine	29009	0.87 ± 0.06	0.019	16 months	Histidine Metabolism
DL-Tryptophan	27897	0.74 ± 0.11	0.020	12 and 16 months	NA
Threonine / D-allo-Threonine	16857	0.77 ± 0.09	0.038	16 months	Glycine and Serine Metabolism / Threonine and 2-Oxobutanoate Degradation / Transcription/Translation

Nominal p-values reported, associated pathway obtained from Profilomics database

ISSN: 1750-1326