Fig. 1
From: The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease
TREM2 expression is significantly reduced in AD mice expressing the Trem2 R47H variant. a Immunohistochemistry was used to identify myeloid cells (IBA1, green), plaques (6E10, blue), and TREM2 (red). b Trem2 RNA levels were assessed in cortical and hippocampal lysates from APPPS1–21;Trem2+/+ (n = 14), APPPS1–21;Trem2+/− (n = 13), and APPPS1–21;Trem2+/R47H (n = 10) mice. Data are presented as fold change normalized gene expression relative to Trem2+/+ mice (n = 9). c Images were quantified to assess TREM2-immunoreactive area and (d) the ratio of TREM2 to IBA1 immunoreactive area around plaques (n = 10–13 mice / genotype). Data are presented as mean ± SEM. *p < 0.05; ***p < 0.001; ns - not significant. Representative images are from the cortex