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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease

Fig. 3

Compact plaque number is specifically reduced in mice expressing the Trem2 R47H variant. Quantification of plaque burden was performed in APPPS1–21;Trem2+/+ (n = 15), APPPS1–21;Trem2+/− (n = 13), and APPPS1–21;Trem2+/R47H (n = 10) mice by (a) measuring 6E10 (red) and (b) Thioflavin S (green) positive plaque number and percent area across three cortical and one hippocampal region from 10 to 12 sagittal sections. Higher magnification of cortical (i) and hippocampal (ii) regions are shown. Data are presented as mean ± SEM. *p < 0.05; **p < 0.01

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