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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease

Fig. 4

Neuritic dystrophy is increased in APPPS1–21 mice expressing the Trem2 R47H variant. a Immunohistochemistry was used to quantify dystrophic neurites in APPPS1–21;Trem2+/+ (n = 16), APPPS1–21;Trem2+/− (n = 15), and APPPS1–21;Trem2+/R47H (n = 10) mice by measuring (a) ubiquitin (magenta) and (b) N-terminal APP (n-APP, red) % area across the cortex and hippocampus. c Dystrophic neurite area (ubiquitin, magenta) normalized to plaque (6E10, blue) size was assessed in APPPS1–21;Trem2+/+ (n = 16), APPPS1–21;Trem2+/− (n = 15), and APPPS1–21;Trem2+/R47H (n = 10) mice. d The correlation between ubiquitin positive area and plaque size was plotted for one representative animal per Trem2 genotype and (e) r2 and (f) slope for the linear best fit lines were calculated. Data are presented as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001

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