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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency

Fig. 3

Increased Enzyme Activity is Associated with Increased Enzyme Levels in Grn+/− and Grn−/− Mice. Grn−/− mice exhibited elevated HexA activity in the frontal cortex at age 2–3 months (a, ANOVA effect of Grn, p < 0.0001, Dunnett’s post-hoc test, p = 0.0001), which was associated with reduced HexA protein levels (b, ANOVA effect of Grn, p = 0.0003, Dunnett’s post-hoc test, p = 0.0007). While Grn+/− mice did not exhibit elevated HexA activity at 2–3 months of age, 20 month-old Grn+/− mice exhibited elevated HexA (a, t test, p = 0.037) and GCase (c, t test, p = 0.0408) activity in the frontal cortex. Consistent with this increased activity, Grn+/− mice exhibited elevated HexA (b, t test, p = 0.0262) and GCase (d, t test, p = 0.0222) protein levels. * = p < 0.05, *** = p < 0.001, **** = p < 0.0001. n = 8–19 mice per genotype

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