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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency

Fig. 4

Tmem106b Reduction Does Not Rescue Most Lysosomal Phenotypes of Grn+/− Mice. Frontal cortex samples from 5- to 6-month-old Grn+/− mice exhibited no differences from wild-type in LAMP-1 levels (a) or GCase activity (c), but increased HexA activity (b, **** = ANOVA effect of Grn, p < 0.0001) and Gusb activity (d, ANOVA effect of Grn, p = 0.0009). Tmem106b reduction had no significant effect on LAMP-1, HexA, or GCase in 5- to 6-month-old mice, but significantly reduced Gusb activity (ANOVA effect of Tmem106b, p = 0.0031, * = p < 0.05 by Tukey’s post-hoc test). Frontal cortex samples from 12-month-old Grn+/− mice exhibited increased LAMP-1 levels (e, ** = ANOVA effect of Grn, p = 0.0072), HexA activity (f, **** = ANOVA effect of Grn, p < 0.0001), GCase activity (g, * = ANOVA effect of Grn, p = 0.0179), and Gusb activity (h, ANOVA effect of Grn, p < 0.0001). As in the younger mice, Tmem106b reduction had no significant effect on LAMP-1, HexA, or GCase in 12 month-old mice, but significantly reduced Gusb activity (ANOVA effect of Tmem106b, p = 0.0010, * = p < 0.05, **** = p < 0.0001 by Tukey’s post-hoc test). n = 12 mice per group for 5- to 6-month-old mice and 11–12 mice per group for 12-month-old mice

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