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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases

Fig. 1

Genome-wide SNP association in the joint analysis. a Manhattan plot indicating the SNP association P values. The vertical axis displays the strength of association (−log10 P value) as a function of genomic position, with alternating colors for sequential chromosomes. Genome-wide significant and suggestive loci are labeled with the nearest gene symbol. The thresholds for significant (P < 5 × 10− 8, red horizontal line) and suggestive (P < 1 × 10− 6, blue horizontal line) associations are shown. b-d Quantile-quantile plots for: b all SNPs, including the strongly associated extended haplotype on chromosome 17; c SNPs excluding chromosome 17; and d SNPs excluding genome-wide significant and suggestive loci. The 95% confidence interval for the expected distribution of p-values is shaded

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Molecular Neurodegeneration

ISSN: 1750-1326