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Fig. 10 | Molecular Neurodegeneration

Fig. 10

From: Counteracting roles of MHCI and CD8+ T cells in the peripheral and central nervous system of ALS SOD1G93A mice

Fig. 10

MHCI and CTLs depletion influence the structure and the extent of myelination of motor axons in SOD1 mutant mice (a-c) Representative images of semithin transverse sections of sciatic nerve from NTG, G93A+/+ and G93A-/- mice at 140 d. Bar, 20 μm. (d) Morphometric analysis showing the percentage of distribution of the axonal structure. Arrows in the insets show fibers with an irregular shape (left inset, low convexity) and with a round shape (right inset, high convexity). (e) Morphometric analysis showing the percentage of distribution the axonal diameter. (f) Average g-ratio in the sciatic nerve from NTG, G93A+/+ and G93A-/- mice. The inset shows the calculation (the ratio between B and A area) to obtain the g-ratio for each axon. Data are reported as mean ± SEM from four independent experiment for each genotype; Data are reported as mean ± SEM from four independent experiments for each genotype. °P < 0.05; °°P < 0.01; °°°P < 0.001; °°°°P < 0.0001 (G93A+/+ vs NTG); #P < 0.05; ##P < 0.01; ###P < 0.001; ####P < 0.0001 (G93A-/- vs NTG); *P < 0.05; **P < 0.0; **P < 0.001 (G93A-/- vs G93A+/+) by one-way ANOVA with Tukey’s post analysis or unpaired t-test

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