Fig. 3

MHCI and CTLs depletion promotes motor neuron survival in mSOD1 mice. a, b Representative Nissl-stained lumbar spinal cord sections of NTG; G93A+/+ and G93A−/− mice at 123 d. c Representative Nissl stained lumbar and cervical spinal cord sections of NTG; G93A+/+ and G93A−/− mice at 140 d. Bar, 50 μm. d, e Motor neuron counts. Data are expressed as mean ± SEM of MNs (≥ 400 μm²) per hemisection. At 123 d, four, seven and seven independent experiments were analyzed for NTG, G93A+/+ and, G93A−/− mice, respectively. At 140 d, three, five and five independent experiments were analyzed for NTG, G93A+/+ and, G93A−/− mice, respectively. At 140 d, for the cervical spinal cord, three, five and five independent experiments were analyzed for NTG, G93A+/+ and, G93A−/− mice, respectively. ^°°°P < 0.001; ^°°°° P < 0.0001 (G93A+/+; G93A−/− vs NTG); ^**P < 0.001 (G93A−/− vs G93A+/+) by one-way ANOVA with Tukey’s post analysis