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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain

Fig. 4

Analysis of individual variants in the RA GRS on microglial density in the ventral medial caudate. Published effect sizes on the x-axis have been transformed using a natural logarithm and oriented in the positive direction to align allelic effects (color denotes direction of effect on microglial density). P-values (uncorrected) are two-sided and derived from robust iterated re-weighted least squares regression models, co-varying for age at death, sex, and three EIGENSTRAT principal components

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