Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain

Table 1 Summary of Studies Used to Derive Polygenic Scores

Trait/Disease	Publication	Total study size (cases/controls)^a	# of SNPs in score	SNPs with ROS/MAP MAF > 0.1
AD	Lambert et al., 2013 (Nat. Genet.)	25,580 / 48,466	22	18
CAD	Nikpay et al., 2015 (Nat. Genet.)	60,801 / 123,504	63	54
MS	Patsopoulos et al.,2017 (Biorxiv)	47,351 / 68,284	232	196
PD	Nalls et al., 2014 (Nat. Genet.)	13,708 / 95,282	32	27
RA	Okada et al., 2014 (Nature)	29,880 / 73,758	76	67
Schizophrenia	Psychiatric Genomics Consortium, 2014 (Nature)	36,989 / 113,075	106	100
Telomere length	Codd et al., 2013 (Nat. Genet.)	48,423^b	8	8

^aStudy size represents all subjects analyzed, regardless of study design (i.e. case/control, meta-analysis, and family-based designs) or analysis stage.
^bThe study by Codd et al., 2013 [43] was not a case/control design, as telomere length was evaluated as a continuous outcome. MAF = minor allele frequency. MAP = Rush Memory and Aging Project. ROS = Rush Religious Orders Study

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