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Table 1 Summary of Studies Used to Derive Polygenic Scores

From: Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain

Trait/Disease Publication Total study size (cases/controls)a # of SNPs in score SNPs with ROS/MAP MAF > 0.1
AD Lambert et al., 2013 (Nat. Genet.) 25,580 / 48,466 22 18
CAD Nikpay et al., 2015 (Nat. Genet.) 60,801 / 123,504 63 54
MS Patsopoulos et al.,2017 (Biorxiv) 47,351 / 68,284 232 196
PD Nalls et al., 2014 (Nat. Genet.) 13,708 / 95,282 32 27
RA Okada et al., 2014 (Nature) 29,880 / 73,758 76 67
Schizophrenia Psychiatric Genomics Consortium, 2014 (Nature) 36,989 / 113,075 106 100
Telomere length Codd et al., 2013 (Nat. Genet.) 48,423b 8 8
  1. aStudy size represents all subjects analyzed, regardless of study design (i.e. case/control, meta-analysis, and family-based designs) or analysis stage.
  2. bThe study by Codd et al., 2013 [43] was not a case/control design, as telomere length was evaluated as a continuous outcome. MAF = minor allele frequency. MAP = Rush Memory and Aging Project. ROS = Rush Religious Orders Study