Skip to main content

Advertisement

Table 2 Sample Sizes and Characteristics for Each Analysis

From: Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain

Phenotype N Mean SD Min Max
Neuritic Plaques 985 0.86 0.85 0.00 5.04
Diffuse Plaques 0.73 0.77 0.00 4.61
Neurofibrillary Tangles 0.63 0.76 0.00 6.23
 Sex (F/M) 641/344
APOE ε4 status (−/+) 723/262
 Age at death 89.06 6.39 66.22 108.28
 Dx at last visit (CN/MCI/AD/other) 319/237/343/86
 PMI 8.57 7.59 0.00 85.08
Total Amyloid 952 4.21 4.20 0.00 19.93
 Sex (F/M) 617/335
APOE ε4 status (−/+) 697/255
 Age at death 88.95 6.38 66.22 108.28
 Dx at last visit (CN/MCI/AD/other) 309/230/329/84
 PMI 8.52 7.57 0.00 85.08
Total PHF-Tau 946 6.43 7.70 0.00 78.52
 Sex (F/M) 615/331
APOE ε4 status (−/+) 694/252
 Age at death 88.91 6.38 66.22 108.28
 Dx at last visit (CN/MCI/AD/other) 312/228/326/80
 PMI 8.47 7.56 0.00 85.08
Microglial Density (all regions) 154 191.02 54.88 48.30 348.64
 Sex (F/M) 96/58
APOE ε4 status (−/+) 117/37
 Age at death 89.50 5.15 74.83 101.19
 Dx at last visit (CN/MCI/AD/other) 51/41/58/4
 PMI 7.36 5.97 2.50 54.50
Cognition 1601 −0.01 0.09 −0.48 0.17
 Sex (F/M) 1113/488
APOE ε4 status (−/+) 1 594a 1186/408
 Age at baseline evaluation 1601 86.50 6.81 60.15 108.15
 Dx at last visit (CN/MCI/AD/other) 700/357/436/108
  1. Note: All values of N are given for samples that have data for both the specified phenotype and genome-wide genotypes.
  2. aAPOE ε4 status was obtained separately from genome-wide genotypes, so seven samples with cognitive data did not have APOE ε4 status data available at time of study, CN cognitively normal, Dx diagnosis, F female, M male, MCI mild cognitive impairment, PHF-Tau paired helical filament tau, PMI postmortem interval, SD standard deviation