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Table 2 Sample Sizes and Characteristics for Each Analysis

From: Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain

Phenotype

N

Mean

SD

Min

Max

Neuritic Plaques

985

0.86

0.85

0.00

5.04

Diffuse Plaques

0.73

0.77

0.00

4.61

Neurofibrillary Tangles

0.63

0.76

0.00

6.23

 Sex (F/M)

641/344

APOE ε4 status (−/+)

723/262

 Age at death

89.06

6.39

66.22

108.28

 Dx at last visit (CN/MCI/AD/other)

319/237/343/86

 PMI

8.57

7.59

0.00

85.08

Total Amyloid

952

4.21

4.20

0.00

19.93

 Sex (F/M)

617/335

APOE ε4 status (−/+)

697/255

 Age at death

88.95

6.38

66.22

108.28

 Dx at last visit (CN/MCI/AD/other)

309/230/329/84

 PMI

8.52

7.57

0.00

85.08

Total PHF-Tau

946

6.43

7.70

0.00

78.52

 Sex (F/M)

615/331

APOE ε4 status (−/+)

694/252

 Age at death

88.91

6.38

66.22

108.28

 Dx at last visit (CN/MCI/AD/other)

312/228/326/80

 PMI

8.47

7.56

0.00

85.08

Microglial Density (all regions)

154

191.02

54.88

48.30

348.64

 Sex (F/M)

96/58

APOE ε4 status (−/+)

117/37

 Age at death

89.50

5.15

74.83

101.19

 Dx at last visit (CN/MCI/AD/other)

51/41/58/4

 PMI

7.36

5.97

2.50

54.50

Cognition

1601

−0.01

0.09

−0.48

0.17

 Sex (F/M)

1113/488

APOE ε4 status (−/+)

1 594a

1186/408

 Age at baseline evaluation

1601

86.50

6.81

60.15

108.15

 Dx at last visit (CN/MCI/AD/other)

700/357/436/108

  1. Note: All values of N are given for samples that have data for both the specified phenotype and genome-wide genotypes.
  2. aAPOE ε4 status was obtained separately from genome-wide genotypes, so seven samples with cognitive data did not have APOE ε4 status data available at time of study, CN cognitively normal, Dx diagnosis, F female, M male, MCI mild cognitive impairment, PHF-Tau paired helical filament tau, PMI postmortem interval, SD standard deviation