From: Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain
Phenotype | N | Mean | SD | Min | Max |
---|---|---|---|---|---|
Neuritic Plaques | 985 | 0.86 | 0.85 | 0.00 | 5.04 |
Diffuse Plaques | 0.73 | 0.77 | 0.00 | 4.61 | |
Neurofibrillary Tangles | 0.63 | 0.76 | 0.00 | 6.23 | |
Sex (F/M) | 641/344 | – | – | – | |
APOE ε4 status (−/+) | 723/262 | – | – | – | |
Age at death | 89.06 | 6.39 | 66.22 | 108.28 | |
Dx at last visit (CN/MCI/AD/other) | 319/237/343/86 | – | – | – | |
PMI | 8.57 | 7.59 | 0.00 | 85.08 | |
Total Amyloid | 952 | 4.21 | 4.20 | 0.00 | 19.93 |
Sex (F/M) | 617/335 | – | – | – | |
APOE ε4 status (−/+) | 697/255 | – | – | – | |
Age at death | 88.95 | 6.38 | 66.22 | 108.28 | |
Dx at last visit (CN/MCI/AD/other) | 309/230/329/84 | – | – | – | |
PMI | 8.52 | 7.57 | 0.00 | 85.08 | |
Total PHF-Tau | 946 | 6.43 | 7.70 | 0.00 | 78.52 |
Sex (F/M) | 615/331 | – | – | – | |
APOE ε4 status (−/+) | 694/252 | – | – | – | |
Age at death | 88.91 | 6.38 | 66.22 | 108.28 | |
Dx at last visit (CN/MCI/AD/other) | 312/228/326/80 | – | – | – | |
PMI | 8.47 | 7.56 | 0.00 | 85.08 | |
Microglial Density (all regions) | 154 | 191.02 | 54.88 | 48.30 | 348.64 |
Sex (F/M) | 96/58 | – | – | – | |
APOE ε4 status (−/+) | 117/37 | – | – | – | |
Age at death | 89.50 | 5.15 | 74.83 | 101.19 | |
Dx at last visit (CN/MCI/AD/other) | 51/41/58/4 | – | – | – | |
PMI | 7.36 | 5.97 | 2.50 | 54.50 | |
Cognition | 1601 | −0.01 | 0.09 | −0.48 | 0.17 |
Sex (F/M) | 1113/488 | – | – | – | |
APOE ε4 status (−/+) | 1 594a | 1186/408 | – | – | – |
Age at baseline evaluation | 1601 | 86.50 | 6.81 | 60.15 | 108.15 |
Dx at last visit (CN/MCI/AD/other) | 700/357/436/108 | – | – | – |