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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins

Fig. 3

Alternatively spliced transcripts of np9-typical length likely generated from HML-2 type 2 locus chr3q21.2_K-4. Five cDNA sequences (with sequences of PCR primers deleted) isolated from 2 different ALS and one control sample are multiply aligned with the sequence of HML-2 locus chr3q21.2_K-4 and with respect to 5′ and 3′ exon sequences within the env gene region. Boundaries of the 292-bp region distinguishing HML-2 type 1 and type 2 loci and splice donor (SD) and splice acceptor (SA) sites of canonical rec splicing, the Env/Rec/Np9 translational start site, and the 5′ end of the 3’ LTR are indicated. Note that most of the env gene (i.e. the rec intron 2, see Fig. 1) is omitted from the figure, indicated by the dashed line between the two alignment blocks. Also note that the canonical np9 SD within the env gene is missing in locus chr3q21.2_K-4 (see also ref. [14])

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