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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins

Fig. 4

Boxplots of HERV-K(HML-2) overall transcript levels as measured by RT-qPCR. Overall HML-2 transcript levels were measured in samples from various tissue types from ALS patients and controls employing a previously established strategy amplifying a region within the HML-2 gag gene [30]. The left boxplots depict normalized transcript levels determined for ALS and control samples from cerebellum. Note the higher relative and much more variable transcript levels in cerebellum. The right boxplots depict normalized HML-2 transcript levels for ALS and control samples from tissue types other than cerebellum. Boxplots depict for each tissue type maximum and minimum values, 95th, 75th, 25th and 5th percentiles, and mean and median, as well as measured transcript levels. Note the break in the Y-axis and that hippocampus included only ALS-derived samples. HML-2 transcript levels are given relative to HML-2 transcript levels co-determined for H9-hESC (set to 1, see text). There were no significantly different transcript levels when comparing ALS and control samples within each tissue type for HML-2 (see the paper text). Significant differential expression was found only for HERV-W transcripts in ALS occipital region samples (see Additional file 2: Figure S6)

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